If you're looking for "the best of the best" running shoe, here are my top picks. Of course, the answer will depend a little on what you're looking for, so I have recommendations for various categories.

• Best All Round Shoe. The Altra Escalante is my current all-round favorite. It has plenty of cushioning for its weight, it has a very springy midsole, it lasts well, and it has a shape that's closer to the shape of a human foot than most shoes. It's a great shoe for any runner, including those Starting to run. It's also a fairly easy shoe to find due to its popularity.
• Best Maximalist Shoe: If you want something massively cushioned, then I'd recommend the Saucony Kinvara 8. It's remarkably light and remarkably cushioned, beating Hoka at their own game.
• Best Optimal Shoe: For those looking to trade cushioning for speed, the Nike Zoom Streak LT 3 was my top pick, but the latest version (LT 4) falls short of it's predecessor. There are lots of great optimal running shoes, which provide just enough cushioning with light weight and minimal frills, but all have their weak spots. Probably the best option at the moment is the Altra Vanish-R, which offers great cushioning for just over 5oz/150g.
• Fastest Shoe: If you really want speed, then check out the Nike Vaporfly 4%. It's light, massively cushioned, and has a carbon fiber plate. Nothing comes close, not even the now defunct New Balance RC5000‏‎ or New Balance RC5000v2‏‎. There are a number of caveats; it's really expensive, it's really hard to find, and there's a significant injury risk.
• Best Minimalist Shoe: Merrell Trail Glove. I recommend the trail glove for road running in spite of the 'trail' moniker. It's not a fast shoe by any means, but it's comfortable and will last well.
• All Terrain Shoe. For trail running, I've become a fan of Altra, and I think their best shoe is the the Altra Timp, though the Altra Lone Peak is really close.
• Honorable Mention: It's not really a running shoe, but the Vivobarefoot Ra is comfortable, minimalist and can more or less pass as a dress shoe. I've worn mine to weddings with a suit and they've not looked out of place. You can run in the Ra, but the leather means it doesn't breathe well.