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{{DISPLAYTITLE:Delayed Onset Muscle Soreness (DOMS) for Runners}}DOMS is of critical importance for runners. Unlike many other types of exercise, running requires your muscles to extend under load, absorbing your weight as you land. This extension under load, called eccentric, is a prime cause of DOMS, and while the soreness is delayed, the accompanying weakness is immediate. This eccentric stress is why marathon runners are often hobbling around the day after a race. The good news is that a bout of DOMS inducing exercise provides protection against future DOMS, and so it's a critical part of training. This "Repeated Bout Effect" (RBE) is a core aspect of training, and by intentionally inducing DOMS you can prevent the soreness that occurs after long distance races. The less obvious, but more important benefit is that you also prevent some of the weakness that occurs towards the end of longer races. This is a key benefit to [[Downhill Running]] and especially the [[Treadmill Descent]]. I believe that incorporating Treadmill Descents into my training is the reason I've completed 100-mile races with little muscle soreness. =Introduction =Delayed Onset Muscle Soreness (DOMS) is a familiar experience to most people who exercise. It affects people who weight train and run particularly, and DOMS can produce anything from mild [[Muscle| muscle]] soreness to debilitating pain and weakness. DOMS is caused by eccentric stress, where the muscles working to resist lengthening, such as lowering a weight or absorbing the landing forces of running. [[Downhill Running| Downhill running]] is a particular source of eccentric stress. DOMS not only produces delayed soreness, but immediate weakness that generally lasts a similar length of time. DOMS also produces swelling, tense muscles, reduced coordination and a limited range of motion. A key benefit of DOMS inducing exercise is that a bout of DOMS can give protection against similar future exercise, and the protection lasts for months. This Repeated Bout Effect (RBE) is a critical part of endurance training. Running with the correct [[Cadence]] can help prevent DOMS, and [[Nutrient Timing| taking protein]] after DOMS inducing exercise ]] is one of the best treatments, though [[Why compression clothes| compression clothing]], [[Caffeine| caffeine]] and [[Massage| massage]] can also help. It seems that [[Vitamin C]] may be critical to the RBE.
=What is DOMS?=
The soreness of DOMS generally peaks between 24 and 72 hours after unusual or severe exercise, though soreness may occur sooner after running<ref name="Vickers2001"/>. DOMS is particularly related to eccentric exercise, which is where the muscle works to resist becoming longer, rather than working to contract. When you your muscles absorb the impact of running, this is eccentric exercise, and [[Downhill Running]] is more eccentric than flat or uphill running. The images below show the damage that occurs from eccentric exercise<ref name="FeassonStockholm2002"/> and marathon running<ref name="Warhol-1985"/>:
<gallery widths=300px heights=200px caption="Muscle damage from eccentric exercise (downhill running)">
File:EccentricA.JPG|Muscle before downhill running
</gallery>
=Why is DOMS important?=
Because running involves a lot of eccentric stress, DOMS is common in runners, especially after [[Downhill Running]]. The pain that occurs 24-72 hours after exercise can prevent continued training. However, the biggest issue for long distance runners is that although the pain occurs 24-72 hours after exercise, the weakness peaks after 30 minutes <ref name=<ref name="Marginson-2005"/>/>. If you've ever run a long, steep descent, you'll know the strange feeling of weak numbness that pervades your quads as the effect of the downhill builds up. The Boston Marathon or the latter part of Mount Mitchell Challenge have descents that cause this type of weakness. If you've felt a similar weakness in the latter stages of a marathon, this may not be [[Glycogen]] depletion creating 'the wall', but eccentric muscle damage that will later manifest itself as DOMS. It is suggested that this is the reason the Boston Marathon course is relatively slow, even though it is a net decent.
=What does DOMS mean to you?=
There is some good news in all of this. While excessive eccentric exercise can cause DOMS, doing some eccentric exercise causes the muscles to adapt and to be able to handle eccentric exercise without DOMS <ref name="Y1"/>. There are two ways then of protecting your muscles from DOMS in running; running greater distances, or running downhill. I believe that downhill running that is greatly underutilized in training regimes. Most hill training workouts focus on the uphill segment, and relegate the downhill to recovery. While uphill can produce some benefits, it is the downhill that can provide the greatest advantage. Adding hills into your workout can make you a much stronger runner, and have benefits even on flat race courses. Don't just use the downhill to recover from the uphill, but work on the downhill.
==DOMS Scale==
This is a simplistic scale that I use to evaluate how bad my DOMS symptoms are. This is focused on DOMS of the quads, the most common areas noticed in runners.
{| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;"! DOMS Scale! Stair Test
|-
| 0| You can walk down stairs without discomfort.
|-
| 1| You can walk down stairs with some pain, but there's no need to hold on to the handrail.
|-
| 2| You can walk down stairs with some pain, but you only need to hold on to the handrail for balance.
|-
| 3| You need to put some of your weight on the handrail to descend stairs.
|-
| 4| You need to put nearly all of your weight on the handrail to descend stairs.
|-
| 5| Your quads cannot lower any weight and descending stairs it tricky. Descending stairs involves standing opposite the handrail and locking the leg that is opposite the handrail. Your body is then tilted towards the handrail, using your arms to lower your weight. The leg nearest the handrail is locked straight and once your body is lowered, it takes the weight. Repeat for each step. (Or avoid stairs.)|}==Likert Scale Muscle Soreness==There is a more general scale of muscle soreness that applies to all muscles, but is not focused on DOMS<ref name="Vickers2001"/><ref name="Impellizzeri-2007"/>. {| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;"! Scale! Description|-| 0 | An absence of soreness |-| 1 | A light pain felt only when touched / a vague ache |-| 2 | A moderate pain felt only when touched / a slight persistent pain |-| 3 | A light pain when walking up or down stairs |-| 4 | A light pain when walking on a flat surface / painful |-| 5 | A moderate pain, stiffness or weakness when walking / very painful |-| 6 | A severe pain that limits my ability to move
|}
=What are the symptoms of DOMS?=
The soreness of DOMS is different to other forms of muscle soreness. With DOMS, large areas of the muscle are tender to the touch and painful when the muscle is used. With other forms of muscle soreness the area of tenderness is usually more localized and the pain of massage is sometimes described as a 'good pain'. The pain of DOMS will normally lessen with light exercise such as walking, which is often described as 'loosening' up. However, the soreness of DOMS is not the best indicator of the muscle damage, and similar levels of soreness can result from differing levels of muscle damage<ref name="NosakaNewton2002"/>. In addition, there are other symptoms, such as:
* Reduction in strength<ref name="Saxton-1995"/><ref name="domsiso"/><ref name="Gulick-1996"/><ref name="Paddon-Jones-1997"/>, typically 30-60%<ref name="Baldwin Lanier-2003"/>. (Note that the reduction in strength starts immediately following the damaging exercise and increases over the next 24-48 hours<ref name="Cheung-2003"/>. The initial reduction in strength can be as much as 40%<ref name="Baldwin Lanier-2003"/>.)
* Muscle tenderness. DOMS makes the muscles tender to the touch, and the pain associated with pressure differs between DOMS and normal muscle soreness. With DOMS, the pain is extremely unpleasant and can be nauseating, where normal muscle soreness can be painful, but the pain has a sense of relief and is sometimes call a "good pain." The muscle tenderness can be measured from the "Pressure-Pain Threshold", where pressure is increased until the subject feels pain rather than pressure<ref name="Pearcey-2015"/>.
* Increased passive muscle tension<ref name="Howatson-2008"/>. A muscle suffering from DOMS will often be hard to the touch, even when relaxed as much as possible.
* Swelling of the muscle<ref name="Howatson-2008"/>, which can be seen as a lack of muscle definition in lean individuals.
* Impaired [[Glycogen]] repletion<ref name="Smith-1992"/><ref name="Braun-2003"/>, though higher carbohydrate intake partly offsets the reduction<ref name="Costill-1990"/>. There is some evidence that Glycogen levels continue to drop after DOMS inducing exercise<ref name="Zehnder-2004"/><ref name="Widrick-1992"/>, and the deficiency in glycogen lasts for over 72 hours<ref name="Widrick-1992"/>.
* There are some studies that indicate there are possible changes in muscle fiber recruitment patterns<ref name="Miles-1997"/><ref name="Zhou-1998"/><ref name="Zhou-1996"/>.
=How long does DOMS last?=
It seems likely that exercise characteristics (duration, intensity, etc.) will change the time to recovery<ref name="Vickers-2001"/><ref name="Paschalis-2005"/>. The soreness generally peaks between 24-72 hours after the damaging exercise, but will last at least 4 days<ref name="Paschalis-2005"/>. My personal experience is that DOMS can last for over a week, and I prefer to avoid [[Downhill Running]] in the two weeks before a race, though sometimes I will include it as close as 10 days beforehand.
=The effect of steepness on DOMS=
I have found that steeper descents produce disproportionately severe DOMS. This might be due to the angle of the knee, as most<ref name="Jones-1989"/><ref name="Child-1998"/> (but not all<ref name="Paschalis-2005"/>) studies indicate that the longer a muscle is when being stressed, the greater the DOMS. This effect is most noticeable when using a [[Treadmill]] for [[Downhill Running]], as small changes in angle can produce a big difference in DOMS.
=How to prevent or treat DOMS?=
There are various approaches to preventing or treating DOMS. The table below is a summary of the approaches showing how likely the strategy is to prevent or treat DOMS combined with the possible significant downsides. At the top are those that are likely to help and have no downsides, then those that have no effects or downsides, then those with little benefit and significant downsides.
{| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;"! '''Strategy'''! '''Timing'''! '''Soreness'''! '''Weakness'''! '''Downsides'''
|-
| Repeated Bout Effect| Before (days to months)| Strong evidence of reduced soreness| Some evidence of reduced weakness| None
|-
| [[Nutrient Timing| Carbohydrate and/or protein]]
| After| Some evidence of reduced soreness| Strong evidence of reduced weakness| None
|-
| [[Cadence]]
| During| Some evidence of reduced soreness| Some evidence of reduced soreness| None
|-
| [[Why compression clothes| Compression Clothing]]
| After| Some evidence of reduced soreness| Some evidence of reduced weakness| None
|-
| [[Caffeine]]
| After
| Some evidence of reduced soreness
| Some evidence of reduced weakness| None<sup>a</sup>
|-
| [[Massage]]
| After| Some evidence of reduced soreness| No benefitSome evidence of reduced weakness | None
|-
| [[Warmup]]
| Immediately before| Some evidence of reduced soreness| No benefit| None
|-
| Light Exercise
| After
| Transient pain reduction
| No benefit| None<sup>c</sup>
|-
| TENS| After
| Transient pain reduction
| No benefit| None
|-
| [[Cryotherapy| Icing]]
| After| No benefit| No benefit| None<sup>b</sup>
|-
| Antioxidents| Before and/or After| Mixed evidence| Mixed evidence
| Conflicting evidence of reduced [[Endurance Adaptations]]
|-
| [[Stretching]]
| Before and/or After| No benefit| No benefit|* # [[Stretching]] temporarily weakens muscles* # Can induce DOMS* # Can lead to injury
|-
| [[NSAIDs and Running| NSAIDs]]
| Before and/or After| Most evidence indicates no benefit| Most evidence indicates no benefit| Can impair recovery
|}
Notes
The DOMS that follows an initial bout of eccentric exercise is much less on subsequent similar bouts. This is often called the Repeated Bout Effect (RBE)<ref name="Howatson-2008"/><ref name="Cheung-2003"/>. The initial bout does not have to cause significant soreness or damage<ref name="Clarkson-1987"/>. As few as 2-10 maximal eccentric repetitions can protect against a subsequent larger bout (24-50), but the initial bout must be close to maximal effort<ref name="Brown-1997"/>. By contrast, eight weeks of training with 50% of the maximal eccentric load did not provide protection against a subsequent maximal bout<ref name="Nosaka-2002"/>. There is some cross-over of protection between different forms of exercise. For instance, eccentric weight training protects against soreness and weakness in subsequent downhill running<ref name="Eston-1996"/>. The protection from the RBE is long lived. One study showed that while the initial weakness was not reduced by the RBE, the recovery of strength was much faster for up to 9 months, and soreness was less for up to 6 months<ref name="Nosaka-2001"/>. Another study showed that 30 minutes of downhill running provides protection for between 6 and 9 weeks<ref name="Byrnes-1985"/>. There is evidence that the RBE may rapidly start to provide protection from soreness and weakness<ref name="Mair-1995"/>, within 5 days<ref name="Ebbeling-1989"/>, and possibly within 24 hours<ref name="Chen-2001"/>. One study<ref name="Brockett-2001"/> demonstrated a change in the length-tension curve of DOMS trained muscles. As shown on the chart below, 7 days after a bout of DOMS inducing exercise the hamstring is able to generate more force and generate it at a greater angle.
[[File:Length Tension Curve and DOMS.jpg|none|thumb|500px|A chart of a subject before and 7 days after DOMS inducing hamstring exercise. The chart shows the angle and the torque developed, indicating that after training the hamstrings are not only stronger, but are able to generate power at significantly longer length. This may be part of the underlying mechanism for the repeated bout effect.]]
===Repeated Bout and Vitamin C===
I found a single study that looked at how the repeated bout effect changes with [[Vitamin C]]<ref name="HeHockemeyer2015"/>. As described below, most studies have found a small reduction in DOMS with Vitamin C. This 2014 study found that for the first bout, Vitamin C reduced the muscle soreness for the hamstrings, Quads, and Tibialis Anterior (shin), but the soreness of the glutes and calves were similar. However, for the second bout, not only was the soreness was reduced for the placebo, but it was further reduced with the Vitamin C. While this is just one study, it is intriguing with some profound implications. If the protective benefits of the repeated bout effect are dependent on nutritional (or other) factors, some runners may not get the benefit from their training. Personally, I've been taking ~1g/day of Vitamin C for many years due to [[Epidermolysis Bullosa| skin condition]]. However, the evidence that Vitamin C impairs the adaptation to exercise caused me to take a break for about 15 months. During that break from Vitamin C, I found my ability to perform downhill running was quite impaired, and I didn't seem to be able to build up resistance from the repeated bout effect.
[[File:Does Combined Antioxidant Vitamin Supplementation Blunt Repeated Bout Effect.jpg|center|thumb|500px|]]
==Carbohydrate and Protein==
{{Main| Nutrient Timing}}
==Compression Clothing ==
{{Main| Why compression clothes}}
Studies show that wearing [[Why compression clothes| Graduated Compression Clothing]] during the days after DOMS inducing exercise mitigates the soreness<ref name="DaviesThompson2009"/><ref name="Kraemer-2001"/><ref name="Kraemer-2001b"/><ref name="KraemerFlanagan2010"/><ref name="Jakeman-2010"/><ref name="Davies-2009"/><ref name="DuffieldPortus2007"/> and weakness<ref name="Kraemer-2001"/><ref name="KraemerFlanagan2010"/><ref name="Jakeman-2010"/> of DOMS. Relatively few studies showed no benefit from compression clothing<ref name="CarlingFrancis1995"/><ref name="Pearce-2009"/>. However, the results of compression clothing are likely to vary with the particular garment, how well it fits and therefore the pressure that is provided<ref name="MacRae-2011"/>. No I found one studies were found that looked at the effect of wearing compression clothing during DOMS inducing exercise on the subsequent recovery<ref name="McDonnellCooper2018"/>. This study used either or both graduated or uniform compression socks on hiking, a trail run, or calf exercise, with the socks also worn for the following four days. Graduated socks reduced DOMS pain on the hike compared with no compression, the only test with no compression as a control. The uniform compression reduced the pain compared with graduated on the run, and there was no difference between them on the calf exercise. This suggests to me that uniform compression might be better than graduated, or at least, it might not be worth paying extra for graduated compression.
==Caffeine==
{{Main| Caffeine}}
==Massage==
{{Main| Massage}}
[[Massage]] is widely used to prevent and treat injuries. Most meta-analysis suggest that post-exercise massage helps with the soreness of DOMS<ref name="Ernst-1998"/><ref name="Moraska-2005"/>, though the mechanisms are unclear<ref name="Tiidus-1997"/>. Studies that give massage 2-3 hours after DOMS inducing exercise showed reduced soreness<ref name="Smith-1994"/><ref name="Zainuddin-2005"/><ref name="Hilbert2003"/>, but not weakness<ref name="Zainuddin-2005"/><ref name="Hilbert2003"/>. One study that gave massage 2 days after exercise that resulted in reduced soreness and improved muscle function<ref name="MancinelliDavis2006"/>, but other studies that use massage 24 hours or more after exercise showed no benefit<ref name="Hart-"/><ref name="Dawson-2004"/>. A study that used 20 minutes of foam rolling immediately following the DOMS inducing exercise, then again at 24 and 48 hours showed a significant improvement in both pain and muscular performance<ref name="Pearcey-2015"/>. Therefore it seems likely that the timing of the massage is important, though other factors, such as the style of massage and the extent of the DOMS may also change the outcome. My personal experience suggests that massage immediately after the exercise is more effective than when the massage is delayed. (All too often, the muscles are too painful under pressure to allow any form of massage.)
==Warmup==
{{Main| Warmup}}
Performing a [[Warmup]] before exercise may help reduce DOMS pain<ref name="Law-2007"/><ref name="RahnamaRahmani-Nia2005"/>, but not all studies support this<ref name="Evans-2002"/>.
==Light Exercise==
Light training in the days following DOMS inducing exercise generally accepted to be one of the most effective ways of reducing muscle soreness, but unfortunately the reduction in pain is temporary<ref name="Armstrong-1984"/><ref name="Zainuddin-2006"/><ref name="Howatson-2008"/><ref name="Cheung-2003"/>. A study that looked at running 30 minutes/day after DOMS inducing downhill running shows that the extra exercise neither helped nor hindered with soreness, weakness or [[Running Economy]]<ref name="ChenNosaka2008"/>. (The study only looked at the 7 days following the downhill running, and it would be interesting to know if there are any longer -term differences.)One study used cycling at light (30%) or moderate (70%) immediately after DOMS inducing exercise<ref name="TufanoBrown2012"/>. The moderate intensity cycling prevented the loss of strength, and actually increased strength on days 3 and 4. There were no differences between the control and the light exercise, nor between any of the conditions for soreness. This is an interesting suggestion that higher intensity exercise might be beneficial, but the study has a number of flaws, including the use of predicted [[Maximum Heart Rate]] to set exercise intensity.
==TENS==
TENS may reduce the soreness of DOMS<ref name="Denegar-1989"/>, but the effect seems to be transient<ref name="Denegar"/> and the effect is reduced if combined with icing<ref name="Denegar-1992"/>. Not all studies show any pain reduction<ref name="Bonacci-1997"/> and none show a reduction in the weakness.
==Icing==
{{Main| Cryotherapy}}
Sadly, [[Cryotherapy| Icing]] does not helpwith DOMS<ref name="Yackzan-"/><ref name="Shunsuke-2004"/><ref name="Gulick-17"/><ref name="Paddon-Jones-1997"/>, and can make DOMS worse<ref name="TsengLee2012"/><ref name="Isabell-1992"/>. Ice reduces pain slightly, but does not restore strength<ref name="Denegar-1992"/> . (In my experience, ice can be extremely effective at helping heal muscle tears and non-DOMS muscle injuries, but not DOMS.)==Protracted Heat==One study looked at applying heat for 8 hours, either directly after DOMS inducing exercise or 24 hours later<ref name="PetrofskyBerk2017"/>. The study used "ThermaCare" chemically generated heat wraps, and I suspect the study was sponsored by the company. The 60 subjects underwent 5 minutes of squats to induce DOMS, then 20 were controls, 20 had immediate heat for 8 hours and the remainder had heat applied 24 hours after exercise. The immediate heat subjects had little reduction in strength over the follow three days, where the 24-hour delayed heat was no different from the controls. The strength drop was about 24% in controls/delayed-heat, which is a meaningful improvement. There was some reduction in pain over the first two days, with the immediate heat doing better than the delayed heat, which was slightly better than the controls.
==Antioxidants - Vitamin C and E==
The evidence for anti-oxidants is mixed, with some studies showing a benefit but not others. Note that one study below showed an impaired recovery with vitamin C supplementation. In addition, there is mixed evidence that vitamin C and/or vitamin E reduces [[Endurance Adaptations]] from exercise<ref name="Gomez-Cabrera-2008"/><ref name="RistowZarse2009"/><ref name="Strobel-2011"/> or they do not<ref name="Wadley-2010"/><ref name="Higashida-2011"/> <ref name="YfantiAkerstrom2009"/>. A 2019 systematic review of 50 studies covering 1,089 subjects concluded that there was moderate quality evidence that Vitamin C reduced DOMS at 48 and 96 hours, with lower quality evidence for 6 and 24 hours, but the reduction was quite small<ref name="RanchordasRogerson2018"/>.{| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;"
! Vitamin C
! Vitamin E
==Stretching==
{{Main| Stretching}}
[[Stretching]] before<ref name="High-1989"/><ref name="Johansson-1999"/> <ref name="Wessel-1994"/>, after <ref name="Johansson-1999"/><ref name="Buroker-1989"/><ref name="Herbert-2007"/>, or both before and after<ref name="Lund-1998"/> exercise does not help with DOMS. In fact, stretching alone can induce DOMS<ref name="Smith-1993"/>. Both static and dynamic stretching are ineffective<ref name="XieFeng2018"/>.==NSAIDs/Pain Relief==
{{Main|NSAIDs and Running}}
The most common NSAIDs (Ibuprofen, Acetaminophen (/Paracetamol), and Aspirin) are unlikely to help with DOMS, but Naproxen may reduce the pain and weakness. (See below for notes on Aspirin and resolvins.) If an NSAID is taken, it should probably be immediately after the damaging exercise rather than waiting until the soreness develops. It seems likely that taking an NSAID for DOMS will reduce the muscular growth that would normally occur as part of the recovery. In one disturbing study, rabbits treated with an NSAID (flurbiprofen) after DOMS inducing exercise initially recovered their strength after 3-7 days, but between days 7 and 28 days the rabbits became weaker while the untreated controls became stronger<ref name="Mishra-1995"/>. I have not included other animal studies, but this is the only one that looks at how NSAIDs impact the longer term recovery from DOMS. There's an emerging belief that NSAIDs suppress inflammation, without actually resolving it<ref name="Markworth Maddipati Cameron-Smith 2016 pp. 110–134"/>. Studies of Turmeric, which acts as a selective COX-2 NSAID<ref name="RamsewakDeWitt2000"/>, are promising. Reduction in soreness is mixed, with some studies showing reduced soreness<ref name="Nicol-2015"/><ref name="Drobnic-2014"/> <ref name="NicolRowlands2015"/>, while others do not<ref name="McFarlinVenable2016"/><ref name="TanabeMaeda2015"/>. However, one study shoes reduced weakness and inflammation markers<ref name="TanabeMaeda2015"/> and an animal study showed less subsequent reduction in running performance in mice<ref name="Davis-2007"/>. Several studies showed reduced markers of damage<ref name="Kawanishi-2013"/><ref name="Davis-2007"/><ref name="TanabeMaeda2015"/><ref name="McFarlinVenable2016"/> <ref name="NicolRowlands2015"/>. However, Turmeric should be treated like any other medication as there are safety concerns; see [[NSAIDs_and_Running#Turmeric_as_an_NSAID| Turmeric as an NSAID]] for details.{| class="wikitable" style="margin-left: auto; margin-right: auto; border: none;"
! NSAID
! Soreness
| 1xNo Effect<ref name="Stone-2002"/>
|
|-
| Turmeric
| 2xImproved<ref name="Nicol-2015"/><ref name="Drobnic-2014"/>
2xNo Effect<ref name="McFarlinVenable2016"/><ref name="TanabeMaeda2015"/>
| 2xImproved<ref name="TanabeMaeda2015"/><ref name="Davis-2007"/>
|}
==HMB (β-hydroxy-β-methylbutyrate)==
There's limited research on HMB and DOMS which suggests HMB might help reduce DOMS<ref name="van SomerenEdwardsHowatson2005"/><ref name="NunanHowatsonvanSomeren2010"/><ref name="KnitterPantonRathmacher2000"/>. The research isn't great, and the results aren't huge, but given the other benefits of [[HMB|HMB For Runners]], I think it's worthwhile. (As an aside, I was amazed to find one study on HMB and DOMS didn't actually use a product containing HMB<ref name="AbumradRathmacher2011"/><ref name="NunanHowatsonvanSomeren2011Ack"/>!)
==CBD Oil==
I have heard anecdotal suggestions that CBD oil may help with sleep after DOMS inducing exercise, but I've found no supporting research. Note that in 2018, World Anti-Doping Agency (WADA) removed CBD, from its 2018 prohibited substances list, but the legality of CBD is complex.
==Omega-3==
There's some limited evidence that Omega-3 oils might help with DOMS<ref name="Anthony Macartney Peoples 2021 pp. 143–153"/>. The Omega-3 oils need to be long chain, such as fish oil, and include EPA and DHA. There's some evidence that athletes may need more Omega-3, with up to 5g/day of EPA/DHA being recommended<ref name="Thielecke Blannin 2020 p. 3712"/>.
==Omega-3, Aspirin, and Resolvins ==
One interesting possibility is the combination of Omega-3 and low dose Aspirin, because Aspirin triggers the conversion of DHA to resolvins<ref name="Dalli Winkler Colas Arnardottir 2013 pp. 188–201"/>. As the name suggests, these resolvins cause the resolution of inflammation rather than simply suppressing inflammation. (Resolvins are not immunosuppressive<ref name="Gilligan Gartung Sulciner Norris 2019 pp. 6292–6297"/>.) While there's no studies on how resolvins interact with DOMS, there's a compelling hypothesis<ref name="Markworth Maddipati Cameron-Smith 2016 pp. 110–134"/> and some initial research into general muscle recovery from injury<ref name="Markworth Maddipati Cameron-Smith 2016 pp. 110–134"/>. The typical dose used to study aspirin triggered resolvins is 81mg after a study comparing 81/325/650mg doses found that 325mg had a negligible improvement over 81mg<ref name="Chiang Bermudez Ridker Hurwitz 2004 pp. 15178–15183"/>. It's unclear if less than 81mg might be effective, as I couldn't find any research into lower doses. (Anecdotally, a medical researcher suggested to me that much lower doses might be sufficient.)
[[File:Resolvins .jpg|400px|thumb|center|The time course of inflammation.]]
=Menstrual Cycle=
A study has shown that DOMS does not vary with menstrual cycle<ref name="ChaffinBerg2011"/>.
=Mechanisms of DOMS=
The underlying mechanism of DOMS is thought to consist of phases; the initial damage that occurs during the exercise and then secondary damage that occurs subsequently<ref name="Cheung-2003"/><ref name="Howatson-2008"/>:
** '''Increased passive muscle stiffness'''. In contrast, passive stiffness is when the muscles are relaxed. It is unclear if increased passive stiffness protects against eccentric damage or actually exacerbates it.
* '''Cellular adaptation. '''A number of changes at the cellular level may provide protection against eccentric damage.
** '''Increased sarcomeres. '''The sarcomeres are part of the contracting mechanism of the muscles. The contraction of a muscle comes from parts of the sarcomere sliding over each other. One adaptation to eccentric exercise may be that the overlap in these sliding areas becomes larger. A study in rats suggests that the adaptation may include more sarcomeres in series, which produces a greater Range Of Motion and greater force at longer muscle lengths<ref name="Lynn-1998"/>.
** '''Changed inflammation response. '''The delay in soreness is probably due to a delayed inflammatory response, so changes in that response could reduce the soreness. However, this would not reduce the immediate loss of strength.
** '''Maintenance of Excitation-Contraction coupling'''. One reason for the loss of strength following eccentric exercise is that the nerve impulses (excitation) may result in less contraction. The decoupling could be due to lack of neural drive (perhaps due to pain), physical disruption of the contracting structures of the muscle, or a failure to activate those contracting structures.
=References=
<references>
<ref name="Paschalis-2005">V. Paschalis, Y. Koutedakis, AZ. Jamurtas, V. Mougios, V. Baltzopoulos, Equal volumes of high and low intensity of eccentric exercise in relation to muscle damage and performance., J Strength Cond Res, volume 19, issue 1, pages 184-8, Feb 2005, doi [http://dx.doi.org/10.1519/R-14763.1 10.1519/R-14763.1], PMID [http://www.ncbi.nlm.nih.gov/pubmed/15705032 15705032]</ref>
<ref name="ChaffinBerg2011">Morgan E. Chaffin, Kris E. Berg, Jessica R. Meendering, Tamra L. Llewellyn, Jeffrey A. French, Jeremy E. Davis, Interleukin-6 and Delayed Onset Muscle Soreness Do Not Vary During the Menstrual Cycle, Research Quarterly for Exercise and Sport, volume 82, issue 4, 2011, pages 693–701, ISSN [http://www.worldcat.org/issn/0270-1367 0270-1367], doi [http://dx.doi.org/10.1080/02701367.2011.10599806 10.1080/02701367.2011.10599806]</ref>
<ref name="ChenNosaka2008">Trevor C. Chen, Kazunori Nosaka, Chia-Ching Wu, Effects of a 30-min running performed daily after downhill running on recovery of muscle function and running economy, Journal of Science and Medicine in Sport, volume 11, issue 3, 2008, pages 271–279, ISSN [http://www.worldcat.org/issn/14402440 14402440], doi [http://dx.doi.org/10.1016/j.jsams.2007.02.015 10.1016/j.jsams.2007.02.015]</ref>
<ref name="Child-1998"> RB. Child, JM. Saxton, AE. Donnelly, Comparison of eccentric knee extensor muscle actions at two muscle lengths on indices of damage and angle-specific force production in humans., J Sports Sci, volume 16, issue 4, pages 301-8, May 1998, doi [http://dx.doi.org/10.1080/02640419808559358 10.1080/02640419808559358], PMID [http://www.ncbi.nlm.nih.gov/pubmed/9663954 9663954]</ref>
<ref name="Jones-1989"> DA. Jones, DJ. Newham, C. Torgan, Mechanical influences on long-lasting human muscle fatigue and delayed-onset pain., J Physiol, volume 412, pages 415-27, May 1989, PMID [http://www.ncbi.nlm.nih.gov/pubmed/2600839 2600839]</ref>
<ref name="SmithGeorge1995">Lucille Smith, Robert George, Thomas Chenier, Michael McCammon, Joseph Houmard, Richard Israel, R. A. Hoppmann, Susan Smith, Do over-the-counter analgesics reduce delayed onset muscle soreness and serum creatine kinase values?, Research in Sports Medicine, volume 6, issue 2, 1995, pages 81–88, ISSN [http://www.worldcat.org/issn/1543-8627 1543-8627], doi [http://dx.doi.org/10.1080/15438629509512039 10.1080/15438629509512039]</ref>
<ref name="Baldwin-2001"> AC. Baldwin, SW. Stevenson, GA. Dudley, Nonsteroidal anti-inflammatory therapy after eccentric exercise in healthy older individuals., J Gerontol A Biol Sci Med Sci, volume 56, issue 8, pages M510-3, Aug 2001, PMID [http://www.ncbi.nlm.nih.gov/pubmed/11487604 11487604]</ref>
<ref name="pmid12580656">author Tokmakidis SP, Kokkinidis EA, Smilios I, Douda H, The effects of ibuprofen on delayed muscle soreness and muscular performance after eccentric exercise., J Strength Cond Res, 2003, volume 17, issue 1, pages 53-9, PMID [http://www.ncbi.nlm.nih.gov/pubmed/12580656 12580656] </ref>
<ref name="Stone-2002"> MB. Stone, MA. Merrick, CD. Ingersoll, JE. Edwards, Preliminary comparison of bromelain and Ibuprofen for delayed onset muscle soreness management., Clin J Sport Med, volume 12, issue 6, pages 373-8, Nov 2002, PMID [http://www.ncbi.nlm.nih.gov/pubmed/12466693 12466693]</ref>
<ref name="RahnamaRahmani-Nia2005">N Rahnama, F Rahmani-Nia, K Ebrahim, The isolated and combined effects of selected physical activity and ibuprofen on delayed-onset muscle soreness, Journal of Sports Sciences, volume 23, issue 8, 2005, pages 843–850, ISSN [http://www.worldcat.org/issn/0264-0414 0264-0414], doi [http://dx.doi.org/10.1080/02640410400021989 10.1080/02640410400021989]</ref>
<ref name="Derrick-1998"> TR. Derrick, J. Hamill, GE. Caldwell, Energy absorption of impacts during running at various stride lengths., Med Sci Sports Exerc, volume 30, issue 1, pages 128-35, Jan 1998, PMID [http://www.ncbi.nlm.nih.gov/pubmed/9475654 9475654]</ref>
<ref name="Clarke-1985"> TE. Clarke, LB. Cooper, CL. Hamill, DE. Clark, The effect of varied stride rate upon shank deceleration in running., J Sports Sci, volume 3, issue 1, pages 41-9, 1985, doi [http://dx.doi.org/10.1080/02640418508729731 10.1080/02640418508729731], PMID [http://www.ncbi.nlm.nih.gov/pubmed/4094019 4094019]</ref>
<ref name="NosakaNewton2002">Kazunori Nosaka, Mike Newton, Paul Sacco, Delayed-onset muscle soreness does not reflect the magnitude of eccentric exercise-induced muscle damage, Scandinavian Journal of Medicine & Science in Sports, volume 12, issue 6, 2002, pages 337–346, ISSN [http://www.worldcat.org/issn/09057188 09057188], doi [http://dx.doi.org/10.1034/j.1600-0838.2002.10178.x 10.1034/j.1600-0838.2002.10178.x]</ref>
<ref name="Vickers-2001"> AJ. Vickers, Time course of muscle soreness following different types of exercise., BMC Musculoskelet Disord, volume 2, pages 5, 2001, PMID [http://www.ncbi.nlm.nih.gov/pubmed/11701094 11701094]</ref>
<ref name="Lynn-1998">R. Lynn, JA. Talbot, DL. Morgan, Differences in rat skeletal muscles after incline and decline running., J Appl Physiol (1985), volume 85, issue 1, pages 98-104, Jul 1998, PMID [http://www.ncbi.nlm.nih.gov/pubmed/9655761 9655761]</ref>
<ref name="Vickers2001">Andrew J Vickers, BMC Musculoskeletal Disorders, volume 2, issue 1, 2001, pages 5, ISSN [http://www.worldcat.org/issn/14712474 14712474], doi [http://dx.doi.org/10.1186/1471-2474-2-5 10.1186/1471-2474-2-5]</ref>
<ref name="Impellizzeri-2007">FM. Impellizzeri, NA. Maffiuletti, Convergent evidence for construct validity of a 7-point likert scale of lower limb muscle soreness., Clin J Sport Med, volume 17, issue 6, pages 494-6, Nov 2007, doi [http://dx.doi.org/10.1097/JSM.0b013e31815aed57 10.1097/JSM.0b013e31815aed57], PMID [http://www.ncbi.nlm.nih.gov/pubmed/17993794 17993794]</ref>
<ref name="Pearcey-2015">GE. Pearcey, DJ. Bradbury-Squires, JE. Kawamoto, EJ. Drinkwater, DG. Behm, DC. Button, Foam rolling for delayed-onset muscle soreness and recovery of dynamic performance measures., J Athl Train, volume 50, issue 1, pages 5-13, Jan 2015, doi [http://dx.doi.org/10.4085/1062-6050-50.1.01 10.4085/1062-6050-50.1.01], PMID [http://www.ncbi.nlm.nih.gov/pubmed/25415413 25415413]</ref>
<ref name="RamsewakDeWitt2000">R.S. Ramsewak, D.L. DeWitt, M.G. Nair, Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa, Phytomedicine, volume 7, issue 4, 2000, pages 303–308, ISSN [http://www.worldcat.org/issn/09447113 09447113], doi [http://dx.doi.org/10.1016/S0944-7113(00)80048-3 10.1016/S0944-7113(00)80048-3]</ref>
<ref name="Nicol-2015">LM. Nicol, DS. Rowlands, R. Fazakerly, J. Kellett, Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)., Eur J Appl Physiol, volume 115, issue 8, pages 1769-77, Aug 2015, doi [http://dx.doi.org/10.1007/s00421-015-3152-6 10.1007/s00421-015-3152-6], PMID [http://www.ncbi.nlm.nih.gov/pubmed/25795285 25795285]</ref>
<ref name="Drobnic-2014">F. Drobnic, J. Riera, G. Appendino, S. Togni, F. Franceschi, X. Valle, A. Pons, J. Tur, Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva): a randomised, placebo-controlled trial., J Int Soc Sports Nutr, volume 11, pages 31, 2014, doi [http://dx.doi.org/10.1186/1550-2783-11-31 10.1186/1550-2783-11-31], PMID [http://www.ncbi.nlm.nih.gov/pubmed/24982601 24982601]</ref>
<ref name="McFarlinVenable2016">Brian K. McFarlin, Adam S. Venable, Andrea L. Henning, Jill N. Best Sampson, Kathryn Pennel, Jakob L. Vingren, David W. Hill, Reduced Inflammatory and Muscle Damage Biomarkers following Oral Supplementation with Bioavailable Curcumin, BBA Clinical, 2016, ISSN [http://www.worldcat.org/issn/22146474 22146474], doi [http://dx.doi.org/10.1016/j.bbacli.2016.02.003 10.1016/j.bbacli.2016.02.003]</ref>
<ref name="TanabeMaeda2015">Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka, Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin, European Journal of Applied Physiology, volume 115, issue 9, 2015, pages 1949–1957, ISSN [http://www.worldcat.org/issn/1439-6319 1439-6319], doi [http://dx.doi.org/10.1007/s00421-015-3170-4 10.1007/s00421-015-3170-4]</ref>
<ref name="Davis-2007">JM. Davis, EA. Murphy, MD. Carmichael, MR. Zielinski, CM. Groschwitz, AS. Brown, JD. Gangemi, A. Ghaffar, EP. Mayer, Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage., Am J Physiol Regul Integr Comp Physiol, volume 292, issue 6, pages R2168-73, Jun 2007, doi [http://dx.doi.org/10.1152/ajpregu.00858.2006 10.1152/ajpregu.00858.2006], PMID [http://www.ncbi.nlm.nih.gov/pubmed/17332159 17332159]</ref>
<ref name="Kawanishi-2013">N. Kawanishi, K. Kato, M. Takahashi, T. Mizokami, Y. Otsuka, A. Imaizumi, D. Shiva, H. Yano, K. Suzuki, Curcumin attenuates oxidative stress following downhill running-induced muscle damage., Biochem Biophys Res Commun, volume 441, issue 3, pages 573-8, Nov 2013, doi [http://dx.doi.org/10.1016/j.bbrc.2013.10.119 10.1016/j.bbrc.2013.10.119], PMID [http://www.ncbi.nlm.nih.gov/pubmed/24184481 24184481]</ref>
<ref name="PetrofskyBerk2017">Jerrold Petrofsky, Lee Berk, Gurinder Bains, Iman Akef Khowailed, Haneul Lee, Michael Laymon, The Efficacy of Sustained Heat Treatment on Delayed-Onset Muscle Soreness, Clinical Journal of Sport Medicine, volume 27, issue 4, 2017, pages 329–337, ISSN [http://www.worldcat.org/issn/1050-642X 1050-642X], doi [http://dx.doi.org/10.1097/JSM.0000000000000375 10.1097/JSM.0000000000000375]</ref>
<ref name="XieFeng2018">Yanfei Xie, Beibei Feng, Kedi Chen, Lars L. Andersen, Phil Page, Yuling Wang, The Efficacy of Dynamic Contract-Relax Stretching on Delayed-Onset Muscle Soreness Among Healthy Individuals, Clinical Journal of Sport Medicine, volume 28, issue 1, 2018, pages 28–36, ISSN [http://www.worldcat.org/issn/1050-642X 1050-642X], doi [http://dx.doi.org/10.1097/JSM.0000000000000442 10.1097/JSM.0000000000000442]</ref>
<ref name="NicolRowlands2015">Lesley M. Nicol, David S. Rowlands, Ruth Fazakerly, John Kellett, Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS), European Journal of Applied Physiology, volume 115, issue 8, 2015, pages 1769–1777, ISSN [http://www.worldcat.org/issn/1439-6319 1439-6319], doi [http://dx.doi.org/10.1007/s00421-015-3152-6 10.1007/s00421-015-3152-6]</ref>
<ref name="McDonnellCooper2018">Adam C McDonnell, Diane Cooper, Tinkara Mlinar, Igor B Mekjavic, The effect of post-exercise application of either graduated or uniform compression socks on the mitigation of delayed onset muscle soreness, Textile Research Journal, 2018, pages 004051751878000, ISSN [http://www.worldcat.org/issn/0040-5175 0040-5175], doi [http://dx.doi.org/10.1177/0040517518780002 10.1177/0040517518780002]</ref>
<ref name="TufanoBrown2012">James J. Tufano, Lee E. Brown, Jared W. Coburn, Kavin K.W. Tsang, Vanessa L. Cazas, Joe W. LaPorta, Effect of Aerobic Recovery Intensity on Delayed-Onset Muscle Soreness and Strength, Journal of Strength and Conditioning Research, volume 26, issue 10, 2012, pages 2777–2782, ISSN [http://www.worldcat.org/issn/1064-8011 1064-8011], doi [http://dx.doi.org/10.1519/JSC.0b013e3182651c06 10.1519/JSC.0b013e3182651c06]</ref>
<ref name="RanchordasRogerson2018">Mayur K Ranchordas, David Rogerson, Hora Soltani, Joseph T Costello, Antioxidants for preventing and reducing muscle soreness after exercise: a Cochrane systematic review, British Journal of Sports Medicine, 2018, pages bjsports-2018-099599, ISSN [http://www.worldcat.org/issn/0306-3674 0306-3674], doi [http://dx.doi.org/10.1136/bjsports-2018-099599 10.1136/bjsports-2018-099599]</ref>
<ref name="AbumradRathmacher2011">Naji N Abumrad, John A Rathmacher, Exercise-Induced Muscle Damage is Not Attenuated by Maximuscle β-Hydroxy-β-Methylbutyrate-1000™ Supplementation, Journal of Strength and Conditioning Research, date July 2011, volume 25, issue 7, pages 1–2, ISSN [http://www.worldcat.org/issn/1064-8011 1064-8011], doi [http://dx.doi.org/10.1519/JSC.0b013e3181f7c3a8 10.1519/JSC.0b013e3181f7c3a8], PMID [http://www.ncbi.nlm.nih.gov/pubmed/21555959 21555959]</ref>
<ref name="HeHockemeyer2015">F. He, J. Hockemeyer, D. Sedlock, Does Combined Antioxidant Vitamin Supplementation Blunt Repeated Bout Effect?, International Journal of Sports Medicine, volume 36, issue 05, 2015, pages 407–413, ISSN [http://www.worldcat.org/issn/0172-4622 0172-4622], doi [http://dx.doi.org/10.1055/s-0034-1395630 10.1055/s-0034-1395630]</ref>
<ref name="van SomerenEdwardsHowatson2005">Ken A. van Someren, Adam J. Edwards, Glyn Howatson, Supplementation with β-Hydroxy- β-Methylbutyrate (HMB) and α-Ketoisocaproic Acid (KIC) Reduces Signs and Symptoms of Exercise-Induced Muscle Damage in Man, International Journal of Sport Nutrition and Exercise Metabolism, date August 2005, volume 15, issue 4, pages 413–424, ISSN [http://www.worldcat.org/issn/1526-484X 1526-484X], 1543-2742 !!eissn!!, doi [http://dx.doi.org/10.1123/ijsnem.15.4.413 10.1123/ijsnem.15.4.413], PMID [http://www.ncbi.nlm.nih.gov/pubmed/16286672 16286672]</ref>
<ref name="NunanHowatsonvanSomeren2010">David Nunan, Glyn Howatson, Ken A van Someren, Exercise-Induced Muscle Damage Is Not Attenuated by β-Hydroxy-β-Methylbutyrate and α-Ketoisocaproic Acid Supplementation, Journal of Strength and Conditioning Research, date February 2010, volume 24, issue 2, pages 531–537, ISSN [http://www.worldcat.org/issn/1064-8011 1064-8011], doi [http://dx.doi.org/10.1519/JSC.0b013e3181c4d370 10.1519/JSC.0b013e3181c4d370], PMID [http://www.ncbi.nlm.nih.gov/pubmed/20072045 20072045]</ref>
<ref name="KnitterPantonRathmacher2000">A. E. Knitter, L. Panton, J. A. Rathmacher, A. Petersen, R. Sharp, Effects of β-hydroxy-β-methylbutyrate on muscle damage after a prolonged run, Journal of Applied Physiology, date 1 October 2000, volume 89, issue 4, pages 1340–1344, ISSN [http://www.worldcat.org/issn/8750-7587 8750-7587], 1522-1601 !!eissn!!, doi [http://dx.doi.org/10.1152/jappl.2000.89.4.1340 10.1152/jappl.2000.89.4.1340], PMID [http://www.ncbi.nlm.nih.gov/pubmed/11007567 11007567]</ref>
<ref name="NunanHowatsonvanSomeren2011Ack">David Nunan, Glyn Howatson, Ken van Someren, Exercise-induced muscle damage is not attenuated by β-hydroxy-β-methylbutyrate and α-ketoisocaproic acid supplementation'., Journal of Strength and Conditioning Research, date July 2011, volume 25, issue 7, page 2, ISSN [http://www.worldcat.org/issn/1064-8011 1064-8011], doi [http://dx.doi.org/10.1097/01.JSC.0000399726.36961.6c 10.1097/01.JSC.0000399726.36961.6c]</ref>
<ref name="Anthony Macartney Peoples 2021 pp. 143–153">Ryan Anthony, Michael J. Macartney, Gregory E. Peoples, The Influence of Long-Chain Omega-3 Fatty Acids on Eccentric Exercise-Induced Delayed Muscle Soreness: Reported Outcomes Are Compromised by Study Design Issues, International Journal of Sport Nutrition and Exercise Metabolism, volume 31, issue 2, date 2021-03-01, ISSN [http://www.worldcat.org/issn/1526-484X 1526-484X], doi [http://dx.doi.org/10.1123/ijsnem.2020-0238 10.1123/ijsnem.2020-0238], pages 143–153</ref>
<ref name="Thielecke Blannin 2020 p. 3712">Frank Thielecke, Andrew Blannin, Omega-3 Fatty Acids for Sport Performance—Are They Equally Beneficial for Athletes and Amateurs? A Narrative Review, Nutrients, volume 12, issue 12, date 2020-11-30, ISSN [http://www.worldcat.org/issn/2072-6643 2072-6643], PMID [http://www.ncbi.nlm.nih.gov/pubmed/33266318 33266318], 7760705 !!pmc!!, doi [http://dx.doi.org/10.3390/nu12123712 10.3390/nu12123712], free !!doi-access!!, page 3712</ref>
<ref name="Dalli Winkler Colas Arnardottir 2013 pp. 188–201">Jesmond Dalli, Jeremy W. Winkler, Romain A. Colas, Hildur Arnardottir, Chien-Yee C. Cheng, Nan Chiang, Nicos A. Petasis, Charles N. Serhan, Resolvin D3 and Aspirin-Triggered Resolvin D3 Are Potent Immunoresolvents, Chemistry & Biology, volume 20, issue 2, date 2013, PMID [http://www.ncbi.nlm.nih.gov/pubmed/23438748 23438748], 3583372 !!pmc!!, doi [http://dx.doi.org/10.1016/j.chembiol.2012.11.010 10.1016/j.chembiol.2012.11.010], pages 188–201</ref>
<ref name="Gilligan Gartung Sulciner Norris 2019 pp. 6292–6297">Molly M. Gilligan, Allison Gartung, Megan L. Sulciner, Paul C. Norris, Vikas P. Sukhatme, Diane R. Bielenberg, Sui Huang, Mark W. Kieran, Charles N. Serhan, Dipak Panigrahy, Aspirin-triggered proresolving mediators stimulate resolution in cancer, Proceedings of the National Academy of Sciences, volume 116, issue 13, date 2019-03-26, ISSN [http://www.worldcat.org/issn/0027-8424 0027-8424], PMID [http://www.ncbi.nlm.nih.gov/pubmed/30862734 30862734], 6442621 !!pmc!!, doi [http://dx.doi.org/10.1073/pnas.1804000116 10.1073/pnas.1804000116], pages 6292–6297</ref>
<ref name="Chiang Bermudez Ridker Hurwitz 2004 pp. 15178–15183">Nan Chiang, Edmund A. Bermudez, Paul M. Ridker, Shelley Hurwitz, Charles N. Serhan, Aspirin triggers antiinflammatory 15-epi-lipoxin A 4 and inhibits thromboxane in a randomized human trial, Proceedings of the National Academy of Sciences, volume 101, issue 42, date 2004-10-19, ISSN [http://www.worldcat.org/issn/0027-8424 0027-8424], PMID [http://www.ncbi.nlm.nih.gov/pubmed/15471991 15471991], 523452 !!pmc!!, doi [http://dx.doi.org/10.1073/pnas.0405445101 10.1073/pnas.0405445101], pages 15178–15183</ref>
<ref name="Markworth Maddipati Cameron-Smith 2016 pp. 110–134">James F. Markworth, Krishna Rao Maddipati, David Cameron-Smith, Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury, Exercise Immunology Review, volume 22, date 2016, ISSN [http://www.worldcat.org/issn/1077-5552 1077-5552], PMID [http://www.ncbi.nlm.nih.gov/pubmed/26853678 26853678], pages 110–134</ref>
<ref name="Markworth Maddipati Cameron-Smith 2016 pp. 110–134">James F. Markworth, Krishna Rao Maddipati, David Cameron-Smith, Emerging roles of pro-resolving lipid mediators in immunological and adaptive responses to exercise-induced muscle injury, Exercise Immunology Review, volume 22, date 2016, ISSN [http://www.worldcat.org/issn/1077-5552 1077-5552], PMID [http://www.ncbi.nlm.nih.gov/pubmed/26853678 26853678], pages 110–134</ref>
</references>