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I suffer from migraines and I found that the joint supplement MSM[1] was making things worse. While I was taking MSM as part of a joint supplement, the problem was not obvious. It was not until I obtained some pure MSM and took a higher dose that I realized the link. The higher dose of MS M triggered one of my worst ever migraines. Stopping the MSM completely reduced the feeling of a migraine in the background.
If you suffer from Migraines, but sure to read [[Magnesium, my favorite micronutrient]]
[1] [http://en.wikipedia.org/wiki/Methylsulfonylmethane http://en.wikipedia.org/wiki/Methylsulfonylmethane]