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==Intermittent Hypoxic Exposure and Diseases==
IHE has been looked at for a number of diseases<ref name="XiSerebrovskaya2012"/>.
===Intermittent Hypoxic Exposure and Asthma===
Studies have reported an improvement in asthma, with reduced attacks, reduced severity of attacks and reduced need for medication. Note that none of these studies has looked at specifically at exercise induced asthma.
* IHE reduced the bronchial resistivity by 31–37% in bronchial asthma patients<ref name="Levashov-2012"/>. IHE also increased reserves of lung ventilation, restored the physiological level of alveolar ventilation in 78% of patients with chronic obstructive pulmonary disease (COPD)<ref name="Levashov-2012"/>.
* Studies have shown IHE reduces the oxidant stress associated with bronchial asthma, however, the study had large variations in individual response<ref name="USSR"/>.
===Neuroprotective Mechanisms of Intermittent Hypoxia===
There are a number of studies that show that mild hypoxic exposure provides neural protection against prolonged [http://en.wikipedia.org/wiki/Ischemia ischemia]<ref name="SkiboOrlovsky2012"/>. This may provide benefits to those with a high risk of stroke, or other risk of impaired blood flow to the brain.
===Intermittent Hypoxic Exposure and Parkinson's Disease===
* Studies in rats suggest that continuous exposure to altitude reduces anti-oxidant defenses, but IHE improves those defenses<ref name="USSR"/>.
* A study of workers that cleaned up after Chernobyl nuclear reactor explosion showed that they had higher levels of oxidant stress where higher than normal. Exposing the workers to IHE of 3x (5 min 7-8% [28,000+ ft] O<sub>2</sub> with 5 min normal air) for 14 days significantly reduced the oxidant stress.
==Risks of Hypoxic Exposure==
There is a case study of an individual who had a seizure after hypoxic exposure<ref name="MoniagaGriswold2009"/>. This military officer was undergoing hypoxia training with a Reduced Oxygen Breathing Device. This device is routinely used to protect and prepare for sudden decompression at altitude. The seizure occurred after sleep deprivation (4hr/night for 3 nights) and breathing 7.11% O2, equivalent to 25,000’. Their [[SpO2|SpO<sub>2</sub>]] dropped to 69%, which is lower than what is normally considered the safe lower limit of 75%. There is also a study of rats that indicates hypoxia may increase seizure susceptibility<ref name="Kubová-2007"/>. Therefore it seems prudent for individuals with epilepsy to avoid hypoxic training without specific medical approval.
==A note on terminology==
<ref name="Manukhina-2012">Manukhina, Eugenia B., et al. "Protective Effects of Adaptation to Hypoxia in Experimental Alzheimer’s Disease." Intermittent Hypoxia and Human Diseases. Springer London, 2012. 155-171.</ref>
<ref name="Chen-2012">Chen, Guo-Qiang, and Wei Liu. "Anticancer Effects of Intermittent Hypoxia in Acute Myeloid Leukemia." Intermittent Hypoxia and Human Diseases. Springer London, 2012. 229-238.</ref>
<ref name="XiSerebrovskaya2012">Lei Xi, Tatiana V. Serebrovskaya, Intermittent Hypoxia and Human Diseases, Accessed on 4 September 2013, date 5 June 2012, publisher Springer, isbn 978-1-4471-2906-6</ref>
<ref name="SkiboOrlovsky2012">Galina Skibo, Maxim Orlovsky, Anastasiia Maistrenko, Victor Dosenko, Iryna Lushnikova, Neuroprotective Mechanisms of Intermittent Hypoxia: An In Vitro Study, 2012, pages 173–180, doi [http://dx.doi.org/10.1007/978-1-4471-2906-6_14 10.1007/978-1-4471-2906-6_14]</ref>
<ref name="MoniagaGriswold2009">Natalie C. Moniaga, Cheryl A. Griswold, Loss of Consciousness and Seizure During Normobaric Hypoxia Training, Aviation, Space, and Environmental Medicine, volume 80, issue 5, 2009, pages 485–488, ISSN [http://www.worldcat.org/issn/00956562 00956562], doi [http://dx.doi.org/10.3357/ASEM.2397.2009 10.3357/ASEM.2397.2009]</ref>
<ref name="Kubová-2007"> H. Kubová, P. Mares, Hypoxia-induced changes of seizure susceptibility in immature rats are modified by vigabatrin., Epileptic Disord, volume 9 Suppl 1, pages S36-43, Dec 2007, doi [http://dx.doi.org/10.1684/epd.2007.0150 10.1684/epd.2007.0150], PMID [http://www.ncbi.nlm.nih.gov/pubmed/18319199 18319199]</ref>
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