8,146
edits
Changes
From Fellrnr.com, Running tips
no edit summary
=NSAIDs and DOMS=
[[Delayed Onset Muscle Soreness]] (DOMS) generally occurs between 24 and 72 hours after unusual or severe exercise, especially eccentric exercise like downhill running. NSAIDS have been shown to increase the pain of DOMS, though they may delay its onset<ref name="DomsNsaids"/>, and NSAIDS may also impair healing from DOMS<ref name="um"/>.
=NSAIDs and Intestinal Damage=
As little as one hour of intense cycling can result in indications of small intestinal damage<ref name="van Wijck-2011"/>, and these markers are significantly higher with ibuprofen use<ref name="VAN Wijck-2012"/>.
=NSAIDs and Racing=
Taking NSAIDs in ultramarathon events can improve performance by reducing pain and acute inflammation, but doing so represents a significant risk. There is some evidence<ref name="wser1"/> <ref name="wser2"/> that many runners taking NSAIDs have the same level of pain and greater damage markers compared with non-users. This may be because the runners push themselves to a similar level of pain, with the NSAIDs allowing them to do more damage.
<ref name="um">Ultrarunning magazine, May/June 2010, "Dealing with DOMS"</ref>
<ref name="Dumke-2007">{{Cite journal | last1 = Dumke | first1 = CL. | last2 = Nieman | first2 = DC. | last3 = Oley | first3 = K. | last4 = Lind | first4 = RH. | title = Ibuprofen does not affect serum electrolyte concentrations after an ultradistance run. | journal = Br J Sports Med | volume = 41 | issue = 8 | pages = 492-6; discussion 496 | month = Aug | year = 2007 | doi = 10.1136/bjsm.2006.033597 | PMID = 17331976 }}</ref>
<ref name="VAN Wijck-2012"> {{Cite journal | last1 = VAN Wijck | first1 = K. | last2 = Lenaerts | first2 = K. | last3 = VAN Bijnen | first3 = AA. | last4 = Boonen | first4 = B. | last5 = VAN Loon | first5 = LJ. | last6 = Dejong | first6 = CH. | last7 = Buurman | first7 = WA. | title = Aggravation of exercise-induced intestinal injury by Ibuprofen in athletes. | journal = Med Sci Sports Exerc | volume = 44 | issue = 12 | pages = 2257-62 | month = Dec | year = 2012 | doi = 10.1249/MSS.0b013e318265dd3d | PMID = 22776871 }}</ref><ref name="van Wijck-2011"> {{Cite journal | last1 = van Wijck | first1 = K. | last2 = Lenaerts | first2 = K. | last3 = van Loon | first3 = LJ. | last4 = Peters | first4 = WH. | last5 = Buurman | first5 = WA. | last6 = Dejong | first6 = CH. | title = Exercise-induced splanchnic hypoperfusion results in gut dysfunction in healthy men. | journal = PLoS One | volume = 6 | issue = 7 | pages = e22366 | month = | year = 2011 | doi = 10.1371/journal.pone.0022366 | PMID = 21811592 }}</ref>
</references>
