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From Fellrnr.com, Running tips
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→NSAIDs and Intestinal Damage
[[Delayed Onset Muscle Soreness]] (DOMS) generally occurs between 24 and 72 hours after unusual or severe exercise, especially eccentric exercise like downhill running. NSAIDS have been shown to increase the pain of DOMS, though they may delay its onset<ref name="DomsNsaids"/>, and NSAIDS may also impair healing from DOMS<ref name="um"/>.
=NSAIDs and Intestinal Damage=
As little as one hour of intense cycling can result in indications of small intestinal damage<ref name="van Wijck-2011"/>, . This is believed to be due to the redirection of blood away from the digestive system and these towards the active muscles. These markers are significantly higher with if 400mg ibuprofen useis taken before the exercise<ref name="VAN Wijck-2012"/>.The marker used is Plasma Intestinal Fatty Acid Binding Protein which is an early marker of intestinal necrosis.[[File:Ibuprofen and GI damage.jpg|none|thumb|500px|The level of a marker of intestinal damage during and after 60 minutes of cycling at 70% [[VO2max|V̇O<sub>2</sub>max]].]]
=NSAIDs and Racing=
Taking NSAIDs in ultramarathon events can improve performance by reducing pain and acute inflammation, but doing so represents a significant risk. There is some evidence<ref name="wser1"/> <ref name="wser2"/> that many runners taking NSAIDs have the same level of pain and greater damage markers compared with non-users. This may be because the runners push themselves to a similar level of pain, with the NSAIDs allowing them to do more damage.
