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Ketogenic Mechanism of Action

239 bytes removed, 22:17, 15 November 2013
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* '''Increased Ketone Levels'''. The increase in Ketones is likely to be responsible for a number of the benefits.
** '''AcAc'''. This is fuel for the brain, preferentially used. It also tends to acidify the blood.
** '''BOHB'''. Unclear if there are direct benefits to from BOHB directly.** '''Acetone'''. Originally thought to be an inactive waste product, this has shown to be biologically active in a number of ways. Some suggestions suggest that this might be the mechanism for action for Epilepsy treatment.
* '''Reduced Blood Glucose'''. The Ketogenic Diet tends to reduce and stabilize blood glucose levels, and this is likely to be responsible for some of the benefits.
** Cancer cells require glucose and can't use [[Ketones]].
** Reduced Dietary Intake of Carbohydrates by Obese Subjects Results in Decreased Concentrations of Butyrate and Butyrate-Producing Bacteria in Feces
* '''Blood pH Levels'''. The Ketogenic Diet tends to acidify the blood slightly, and this may have some health impacts.
* '''Reduced Micronutrient Intake'''.
* '''Changes in Blood Lipid Levels'''.
* '''Increased Fat Intake'''. The Ketogenic Diet obviously involves a dramatic increase in the dietary fat intake, which may have some direct benefits, especially around ensuring an adequate supply of essential fats.
* '''Thyroid Changes'''. Studies have shown a reduction in thyroid hormone production, particularly T3. This may contribute to the conservation of Glycogen during exercise. (The human metabolic response to chronic ketosis without caloric restriction- preservation of submaximal exercise capability with reduced carbohydrate oxidation).
* '''Supplementation'''. If patients receive nutrient supplements, then their health might improve because a deficiency has been overcome. (Note that it is not clear if the [[Ketogenic Diet]] changes the Recommended Daily Allowance of nutrients.)
* '''Nutrient Deficiency'''. While nutrient deficiency is typically a [[Health Risks of the Ketogenic Diet| Health Risk of the Ketogenic Diet]], it is possible that a particular deficiency could improve a particular health condition if patients have been getting an excess of a particular nutrient.

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