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From Fellrnr.com, Running tips
→A Summary of the Research on NSAIDs and DOMS
* It seems likely that taking an NSAID for DOMS will reduce the muscular growth that would normally occur as part of the recovery.
** In one study, rabbits treated with flurbiprofen after DOMS inducing exercise regained more strength after 3-7 days, but between days 7 and 28 days the treated rabbits became weaker while the controls became stronger<ref name="Mishra-1995"/>. This is only one study, and on animals, but it is rather troubling as none of the human studies look at the results over this time period.
==A Summary of the Research on NSAIDs and DOMS==The table below summarizes the research I located on the effect of NSAIDs on DOMS in humans. I've only considered the primary DOMS markers of soreness (pain) and weakness, rather than including things like blood enzymes. For each NSAID I've shown how many studies show an improvement and how many studies show no effect.
{| class="wikitable"
!NSAID!!Soreness!!Weakness
|-
|Ibuprofen
|2xImproved<ref name="Hasson-1993"/><ref name="pmid12580656"/>7xNoEffect<ref name="Grossman-1995"/><ref name="Pizza-1999"/><ref name="RahnamaRahmani-Nia2005"/> <ref name="KrentzQuest2008"/><ref name="Arendt-NielsenWeidner2007"/><ref name="Donnelly-1990"/><ref name="Stone-2002"/> 2xYes|1xMaybe<ref name="Hasson-1993"/><ref name="pmid12580656"/>|8xNoEffect<ref name="Grossman-1995"/><ref name="Pizza-1999"/><ref name="RahnamaRahmani-Nia2005"/> <ref name="KrentzQuest2008"/><ref name="Arendt-NielsenWeidner2007"/><ref name="Donnelly-1990"/><ref name="pmid12580656"/><ref name="Stone-2002"/> 1xMaybe<ref name="Hasson-1993"/>
|-
|Acetaminophen (Paracetamol)
|2xNoEffect<ref name="Barlas-2000"/><ref name="SmithGeorge1995"/>
|
|-
|Aspirin
|2xYes2xImproved<ref name="Riasata-2010"/><ref name="Francis-1987"/>2xNoEffect<ref name="Barlas-2000"/><ref name="SmithGeorge1995"/>|2xNoEffect<ref name="Riasata-2010"/><ref name="Francis-1987"/>
|-
|Naproxen
|4xYes4xImproved<ref name="Dudley-1997"/><ref name="Baldwin-2001"/><ref name="Lecomte-1998"/><ref name="journals.ut.ac.ir"/>1xNoEffect<ref name="Bourgeois-1999"/>|3xYes3xImproved<ref name="Dudley-1997"/><ref name="Baldwin-2001"/><ref name="Lecomte-1998"/>1xNoEffect<ref name="Bourgeois-1999"/>
|-
|Diclofenac
|-
|Codeine
|1xNoEffect<ref name="Barlas-2000"/>
|
|-
|Rofecoxib
|1xNoEffect<ref name="LoramMitchell2005"/>
|
|-
|Ketoprofen
|1xYes1xImproved<ref name="Sayers-2001"/>|1xYes1xImproved<ref name="Sayers-2001"/>
|-
|Bromelain
|1xNoEffect<ref name="Stone-2002"/>
|
|}
=NSAIDs and Intestinal Damage=
