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The inflammation response of our bodies is a key part of the healing process. Using NSAIDs to reduce the inflammation has been shown to impair healing in different tissue types:
* '''Muscles'''<ref name="MuscleTrappe"/>. A 2001 study showed that Ibuprofen and Acetaminophen reduce [[Muscle|muscle]] growth after eccentric exercise. Another study<ref name="muscle"/> on muscle damage and NSAIDs showed impaired recovery in the early stages of healing. There was some increased [[Protein]] synthesis with NSAIDs in latter stages of healing, but the muscles were still weaker 28 days after injury. Other studies<ref name="muscle2"/><ref name="muscle3"/> have shown that four days after injury, NSAIDs resulted in very little muscle regeneration compared with no drugs.
* '''Tendons'''. A primate study<ref name="TendonPrimates"/> showed "a marked decrease in the breaking strength of tendons at four and six weeks in the ibuprofen-treated animals". Another animal study<ref name="TendonCOX2"/> showed treated tendons were 32% weaker than their untested counterparts. A study of older adults showed a weakening of tendons with acetaminophen (but not ibuprofen) use<ref name="CarrollDickinson2011"/>.
* '''Bone-Tendon Junctions'''. An animal study<ref name="tendon"/> of rotator cuff injuries shows that NSAID usage resulted in injuries that did not heal, and those that did heal were weaker than those without NSAID. To quote from the study "Given that NSAID administration was discontinued after 14 days yet affected load-to-failure eight weeks following repair, it appears that inhibition of the early events in the inflammatory cascade has a lasting negative effect on tendon-to-bone healing," Dr. Rodeo said.
* '''Cartilage. ''' NSAIDs have been shown<ref name="CartilageRabbit"/> to impair the healing of bone and cartilage in rabbits.
<ref name="TayyemHeath2006">Reema F. Tayyem, Dennis D. Heath, Wael K. Al-Delaimy, Cheryl L. Rock, Curcumin Content of Turmeric and Curry Powders, Nutrition and Cancer, volume 55, issue 2, 2006, pages 126–131, ISSN [http://www.worldcat.org/issn/0163-5581 0163-5581], doi [http://dx.doi.org/10.1207/s15327914nc5502_2 10.1207/s15327914nc5502_2]</ref>
<ref name="NiemanCialdella-Kam2012">David C. Nieman, Lynn Cialdella-Kam, Amy M. Knab, R. Andrew Shanely, Influence of Red Pepper Spice and Turmeric on Inflammation and Oxidative Stress Biomarkers in Overweight Females: A Metabolomics Approach, Plant Foods for Human Nutrition, volume 67, issue 4, 2012, pages 415–421, ISSN [http://www.worldcat.org/issn/0921-9668 0921-9668], doi [http://dx.doi.org/10.1007/s11130-012-0325-x 10.1007/s11130-012-0325-x]</ref>
<ref name="CarrollDickinson2011">C. C. Carroll, J. M. Dickinson, J. K. LeMoine, J. M. Haus, E. M. Weinheimer, C. J. Hollon, P. Aagaard, S. P. Magnusson, T. A. Trappe, Influence of acetaminophen and ibuprofen on in vivo patellar tendon adaptations to knee extensor resistance exercise in older adults, Journal of Applied Physiology, volume 111, issue 2, 2011, pages 508–515, ISSN [http://www.worldcat.org/issn/8750-7587 8750-7587], doi [http://dx.doi.org/10.1152/japplphysiol.01348.2010 10.1152/japplphysiol.01348.2010]</ref>
</references>
[[Category:Training]]
[[Category:Injury]]
[[Category:Science]]
