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* '''Immune system hypothesis'''<ref name="OTDepression"/>. Several case histories of linked [[Overtraining Syndrome]] to a recent infection. Given the depression is the most consistent symptom of infectious diseases in humans, there is a hypothesis that an infection is a triggering event for [[Overtraining Syndrome]]. It is then believed that other mechanisms maintain the depressive state causing prolonged [[Overtraining Syndrome]] symptoms.
* '''Muscle calcium hypothesis'''<ref name="OTPhysioReview"/>. Calcium is part of the mechanism behind muscle contraction and this hypothesis proposes that less calcium is released in overtrained state, which limits muscular contraction. The problem with this hypothesis is that it would only explain physical performance problems, not the immune system or [[Mood State]] changes.
* '''Negative feedback hypothesis'''<ref name="OvertraingInSport"/>. It has been suggested that [[Overtraining Syndrome]] is one of the negative feedback systems in the body that prevents damage, similar to the [[Central Governor Theory]].
=References=
<references>
<ref name="OTCostill">Effects of repeated days of intensified... [Med Sci Sports Exerc. 1988] - PubMed - NCBI http://www.ncbi.nlm.nih.gov/pubmed/3386503 </ref>
<ref name="OTSnyder">Overtraining and glycogen depletion hyp... [Med Sci Sports Exerc. 1998] - PubMed - NCBI http://www.ncbi.nlm.nih.gov/pubmed/9662687 </ref>
<ref name="OvertraingInSport">Overtraining In Sport, Kreider, Fry, O'Toole, Human Kinetics</ref>
</references>
