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Ketogenic Diets for Cancer

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* The unrestricted diet combined with [[Omega 3]] and [[MCT]] delayed the growth of implanted gastric cancer cells in mice<ref name="Otto-2008"/>.
* The ketogenic diet may need to be combined with calorie restriction to ensure lowered glucose levels for the treatment of brain tumors<ref name="Seyfried-2008"/>. A study that compared an unrestricted standard diet, an unrestricted ketogenic diet and a restricted ketogenic diet in mice with implanted brain tumors, only the restricted ketogenic diet improved survival rates<ref name="Zhou-2007"/>.
* Short term fasting can improve the survival rates for mice with implanted brain tumors, and this benefit can enhance both chemotherapy and radiation treatment<ref name="Safdie-2012"/>.
* Drugs are being developed for cancer treatment that target metabolic pathways<ref name="Tennant-2010"/>.
* Giving a no-carbohydrate ketogenic diet to rats with grafted prostate cancer tumors resulted in a 33% smaller tumor size than controls fed a western diet<ref name="Freedland-2008"/>. In another study, rats with grafted prostate cancer tumors given 0%, 10% or 20% carbohydrate had similar survival rates<ref name="Masko-2010"/>.
<ref name="AllenBhatia2013">B. G. Allen, S. K. Bhatia, J. M. Buatti, K. E. Brandt, K. E. Lindholm, A. M. Button, L. I. Szweda, B. J. Smith, D. R. Spitz, M. A. Fath, Ketogenic Diets Enhance Oxidative Stress and Radio-Chemo-Therapy Responses in Lung Cancer Xenografts, Clinical Cancer Research, volume 19, issue 14, 2013, pages 3905–3913, ISSN [http://www.worldcat.org/issn/1078-0432 1078-0432], doi [http://dx.doi.org/10.1158/1078-0432.CCR-12-0287 10.1158/1078-0432.CCR-12-0287]</ref>
<ref name="TangPoff2013">Chih-Hsin Tang, Angela M. Poff, Csilla Ari, Thomas N. Seyfried, Dominic P. D'Agostino, The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer, PLoS ONE, volume 8, issue 6, 2013, pages e65522, ISSN [http://www.worldcat.org/issn/1932-6203 1932-6203], doi [http://dx.doi.org/10.1371/journal.pone.0065522 10.1371/journal.pone.0065522]</ref>
<ref name="Safdie-2012">F. Safdie, S. Brandhorst, M. Wei, W. Wang, C. Lee, S. Hwang, PS. Conti, TC. Chen, VD. Longo, Fasting enhances the response of glioma to chemo- and radiotherapy., PLoS One, volume 7, issue 9, pages e44603, 2012, doi [http://dx.doi.org/10.1371/journal.pone.0044603 10.1371/journal.pone.0044603], PMID [http://www.ncbi.nlm.nih.gov/pubmed/22984531 22984531]</ref>
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