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Delayed Onset Muscle Soreness

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==NSAIDs==
{{Main|NSAIDs and Running}}
The most common NSAIDs (Ibuprofen, Acetaminophen (/Paracetamol), and Aspirin) are unlikely to help with DOMS, but Naproxen may reduce the pain and weakness. If an NSAID is taken, it should probably be immediately after the damaging exercise rather than waiting until the soreness develops. It seems likely that taking an NSAID for DOMS will reduce the muscular growth that would normally occur as part of the recovery. In one disturbing study, rabbits treated with an NSAID (flurbiprofen) after DOMS inducing exercise initially recovered their strength after 3-7 days, but between days 7 and 28 days the rabbits became weaker while the untreated controls became stronger<ref name="Mishra-1995"/>. I have not included other animal studies, but this is the only one that looks at how NSAIDs impact the longer term recovery from DOMS. Studies of Turmeric, which acts as a selective COX-2 NSAID<ref name="RamsewakDeWitt2000"/>, are promising. Reduction in soreness is mixed, with some studies showing reduced soreness<ref name="Nicol-2015"/><ref name="Drobnic-2014"/>, while others do not<ref name="McFarlinVenable2016"/><ref name="TanabeMaeda2015"/>. However, one study shoes reduced weakness and inflammation markers<ref name="TanabeMaeda2015"/> and an animal study showed less subsequent reduction in running performance in mice<ref name="Davis-2007"/>. Several studies showed reduced markers of damage<ref name="Kawanishi-2013"/><ref name="Davis-2007"/><ref name="TanabeMaeda2015"/><ref name="McFarlinVenable2016"/>. However, Turmeric should be treated like any other medication as there are safety concerns; see [[NSAIDs_and_Running#Turmeric_as_an_NSAID| Turmeric as an NSAID]] for details.
{| class="wikitable"
! NSAID
| 1xNo Effect<ref name="Stone-2002"/>
|
|-
| Turmeric
| 2xImproved<ref name="Nicol-2015"/><ref name="Drobnic-2014"/>
2xNo Effect<ref name="McFarlinVenable2016"/><ref name="TanabeMaeda2015"/>
| 2xImproved<ref name="TanabeMaeda2015"/><ref name="Davis-2007"/>
|}
=Menstrual Cycle=
<ref name="Impellizzeri-2007">FM. Impellizzeri, NA. Maffiuletti, Convergent evidence for construct validity of a 7-point likert scale of lower limb muscle soreness., Clin J Sport Med, volume 17, issue 6, pages 494-6, Nov 2007, doi [http://dx.doi.org/10.1097/JSM.0b013e31815aed57 10.1097/JSM.0b013e31815aed57], PMID [http://www.ncbi.nlm.nih.gov/pubmed/17993794 17993794]</ref>
<ref name="Pearcey-2015">GE. Pearcey, DJ. Bradbury-Squires, JE. Kawamoto, EJ. Drinkwater, DG. Behm, DC. Button, Foam rolling for delayed-onset muscle soreness and recovery of dynamic performance measures., J Athl Train, volume 50, issue 1, pages 5-13, Jan 2015, doi [http://dx.doi.org/10.4085/1062-6050-50.1.01 10.4085/1062-6050-50.1.01], PMID [http://www.ncbi.nlm.nih.gov/pubmed/25415413 25415413]</ref>
<ref name="RamsewakDeWitt2000">R.S. Ramsewak, D.L. DeWitt, M.G. Nair, Cytotoxicity, antioxidant and anti-inflammatory activities of Curcumins I–III from Curcuma longa, Phytomedicine, volume 7, issue 4, 2000, pages 303–308, ISSN [http://www.worldcat.org/issn/09447113 09447113], doi [http://dx.doi.org/10.1016/S0944-7113(00)80048-3 10.1016/S0944-7113(00)80048-3]</ref>
<ref name="Nicol-2015">LM. Nicol, DS. Rowlands, R. Fazakerly, J. Kellett, Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)., Eur J Appl Physiol, volume 115, issue 8, pages 1769-77, Aug 2015, doi [http://dx.doi.org/10.1007/s00421-015-3152-6 10.1007/s00421-015-3152-6], PMID [http://www.ncbi.nlm.nih.gov/pubmed/25795285 25795285]</ref>
<ref name="Drobnic-2014">F. Drobnic, J. Riera, G. Appendino, S. Togni, F. Franceschi, X. Valle, A. Pons, J. Tur, Reduction of delayed onset muscle soreness by a novel curcumin delivery system (Meriva): a randomised, placebo-controlled trial., J Int Soc Sports Nutr, volume 11, pages 31, 2014, doi [http://dx.doi.org/10.1186/1550-2783-11-31 10.1186/1550-2783-11-31], PMID [http://www.ncbi.nlm.nih.gov/pubmed/24982601 24982601]</ref>
<ref name="McFarlinVenable2016">Brian K. McFarlin, Adam S. Venable, Andrea L. Henning, Jill N. Best Sampson, Kathryn Pennel, Jakob L. Vingren, David W. Hill, Reduced Inflammatory and Muscle Damage Biomarkers following Oral Supplementation with Bioavailable Curcumin, BBA Clinical, 2016, ISSN [http://www.worldcat.org/issn/22146474 22146474], doi [http://dx.doi.org/10.1016/j.bbacli.2016.02.003 10.1016/j.bbacli.2016.02.003]</ref>
<ref name="TanabeMaeda2015">Yoko Tanabe, Seiji Maeda, Nobuhiko Akazawa, Asako Zempo-Miyaki, Youngju Choi, Song-Gyu Ra, Atsushi Imaizumi, Yoshihiko Otsuka, Kazunori Nosaka, Attenuation of indirect markers of eccentric exercise-induced muscle damage by curcumin, European Journal of Applied Physiology, volume 115, issue 9, 2015, pages 1949–1957, ISSN [http://www.worldcat.org/issn/1439-6319 1439-6319], doi [http://dx.doi.org/10.1007/s00421-015-3170-4 10.1007/s00421-015-3170-4]</ref>
<ref name="Davis-2007">JM. Davis, EA. Murphy, MD. Carmichael, MR. Zielinski, CM. Groschwitz, AS. Brown, JD. Gangemi, A. Ghaffar, EP. Mayer, Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage., Am J Physiol Regul Integr Comp Physiol, volume 292, issue 6, pages R2168-73, Jun 2007, doi [http://dx.doi.org/10.1152/ajpregu.00858.2006 10.1152/ajpregu.00858.2006], PMID [http://www.ncbi.nlm.nih.gov/pubmed/17332159 17332159]</ref>
<ref name="Kawanishi-2013">N. Kawanishi, K. Kato, M. Takahashi, T. Mizokami, Y. Otsuka, A. Imaizumi, D. Shiva, H. Yano, K. Suzuki, Curcumin attenuates oxidative stress following downhill running-induced muscle damage., Biochem Biophys Res Commun, volume 441, issue 3, pages 573-8, Nov 2013, doi [http://dx.doi.org/10.1016/j.bbrc.2013.10.119 10.1016/j.bbrc.2013.10.119], PMID [http://www.ncbi.nlm.nih.gov/pubmed/24184481 24184481]</ref>
</references>

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