Changes

There is evidence<ref name="Helin"/><ref name="Schwellnus2009"/> that as [[Muscle|muscles ]] become tired the activity of the nerves changes. The mechanisms that activate muscle contraction become more active in the mechanisms that inhibit muscle contraction are weakened. This is a particular problem for muscles that will work in a contracted state such as the calf or hamstring and for muscles that do not have the opportunity to relax periodically. There are a number of potential treatments for cramping caused by muscle fatigue beyond the over simplistic and naïve approach of not exercising so hard.