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The scientific evidence around Ketoadaptation is limited as most studies use obese individuals that are undergoing a prolonged fast rather than a [[Ketogenic Diet]].
* Ketoadaptation generally takes a minimum of two weeks, but some aspects may take longer. There is an initial phase of a few days that involves weight loss, mostly from Glycogen/water with some muscle loss, but little fat reduction.
* Ketoadaptation generally requires a reduction in the availability of glucose. This is primarily due to a reduction in the [[Net Carbohydrates| Net Carbohydrate]] intake, but because the body will convert protein to glucose, the intake of protein must also be controlled.
* There is a reduction in [[Glycogen]], both [[Muscle]] Glycogen and liver glycogen. This takes a few days depending on exercise levels and is associated with weight loss as Glycogen is stored with water.
* The levels of blood [[Ketones]] rise and the time between glucose dropping and ketones rising might contribute to the Ketoadaptation period. This rise in Ketone levels is probably due to improved reabsorption by the kidneys and reduced usage by muscles<ref name="Robinson-1980"/>.