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* Ketoadaptation generally takes a minimum of two weeks, but some aspects may take longer.
* There is a reduction in [[Glycogen]], both [[Muscle]] [[Glycogen]] and liver glycogen.
* The levels of blood [[KetoneKetones]]s rise.
* The ratio of Insulin to glucagon changes, with insulin levels falling. This may be a mechanism that triggers the generation of ketones, but in some situations ketones can be produced even with elevated insulin.
* Blood uric acid levels initially rise, before falling to baseline levels after 4-6 weeks. This can cause gout in susceptible individuals.