Changes

* The scientific evidence around ketoadapation Ketoadaptation is limited as most studies use obese individuals that are undergoing a prolonged fastrather than a [[Ketogenic Diet]].* Ketoadaptation generally takes a minimum of two weeks, but some aspects may take longer. There is an initial phase of a few days that involves weight loss, mostly from Glycogen/water with some muscle loss, but little fat reduction.* Ketoadaptation generally requires a reduction in the availability of glucose. This is from primarily due to a reduction in net carbohydrate the [[Net Carbohydrate]] intake, but because the body will convert protein to glucose, the intake of protein must also be controlled.* Ketoadaptation generally takes a minimum of two weeks, but some aspects may take longer. * There is a reduction in [[Glycogen]], both [[Muscle]] [[Glycogen]] and liver glycogen. This takes a few days depending on exercise levels and is associated with weight loss as Glycogen is stored with water.* The levels of blood [[Ketones]] riseand the time between glucose dropping and ketones rising might contribute to the Ketoadaptation period. This rise in Ketone levels is probably due to improved reabsorption by the kidneys and reduced usage by muscles<ref name="Robinson-1980"/>.

* The ratio between the [[Ketones]] AcAc and BOHB appears to change with adaptation.* During ketoadaptation Ketoadaptation the kidneys conserve ketones by reabsorption. ** Studies show that urine ketone excretion generally peaks after 4-8 days of fasting, and then diminishes<ref name="Sapir-1975"/>. (Renal conservation of ketone bodies during starvation)

* Changes in protein metabolism and nitrogen conservation appear to occur within the first few days. For the first few days protein (muscle mass) is lost, but then stabilizes. Muscle mass can be maintained on a remarkably low protein intake when on the [[Ketogenic Diet]].* Changes There are changes in ketone blood/brain barrier.** The , and while the brain will use ketones if they are available, regardless of the level of glucose in ability to transport the ketones from the bloodinto the brain may improve over time.* Ketoadaptation can involve greater impaired memory functioning than subjects on a typical fat diet<ref name="D'Anci-2009"/>. Ketoadaptation can produce increased confusion, though this is slightly less than subjects undergoing a typical low fat diet<ref name="D'Anci-2009"/>.* The fuel usage of muscles changes with ketoadaptationKetoadaptation. ** In sedentary obese individuals on a 24 day fast the forearm muscles reduced the uptake of glucose, increased the intake of ketones (both AcAc and BOHB), and increased the intake of fatty acids<ref name="Owen-1971"/>. (Human forearm metabolism during progressive starvation.)

How There are no indications of how long does it take takes to lose the adaptations?=See Also=Ketoadaptation.